Job Information

J&J Family of Companies Associate Scientist 1, Oligo chemistry in Brisbane, California

Associate Scientist 1, Oligo chemistry - 2306122924W


Janssen Research and Development, a member of Johnson and Johnson's Family of Companies, is recruiting for an Associate Scientist I, Oligonucleotide Chemistry, RNA, Gene Therapy & Delivery within Therapeutics Discovery located in Brisbane, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

RNA, Gene Therapy & Delivery is an organization within Therapeutics Discovery, committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with all six Janssen Therapeutic Areas (TA) discovery teams. Our mission requires critical thinking, a portfolio approach and deep scientific expertise in several fields including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.

Key Responsibilities:

  • Perform end-to-end synthesis, downstream processing, and in-process QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects

  • Optimize methods and improve scale-up capabilities for Oligonucleotide synthesis and purification systems

  • Preparation of buffers and reagents needed for synthesis and purification systems

  • Ensure the supply of laboratory consumables and reagents are in stock as needed

  • Perform LNP formulation for a variety of RNA types at various scales and conduct QC for LNP formulations

  • Provide support to the LNP formulation team with ordering lab materials, making daily buffers, preparing shipments, and labeling and aliquoting samples

  • Maintain a high level of productivity in the laboratory setting.

  • Present data and reports on project status at individual, group, and departmental meetings.


  • M.S. with 1-3 years of experience or a B.S./B.A. with 2-4 years of experience, performing progressively advanced duties at the Assistant Scientist level, or the equivalent training/experience is required.

  • Prior experience in the solid phase synthesis of oligonucleotides and/or nucleoside/nucleotide synthesis and downstream processes is required.

  • Prior experience with LNP formulation and characterization is required.

  • Record of maintaining a strong lab presence is required.

  • Excellent communication and interpersonal skills.

  • Excellent prioritization and organization skills.

  • Ability to collaborate across teams in a matrix environment is required

The anticipated base pay range for this position is $78,800 to $126,960.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit

Primary Location NA-US-California-Brisbane

Organization Janssen Research & Development, LLC (6084)

Job Function Chemistry

Req ID: 2306122924W